CD133/Prominin-1 (PROM1) [MD299]

$296.00$596.00

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CD133, also known as prominin or AC133, is a marker frequently found on multipotent progenitor cells, including immature hematopoietic stem and progenitor cells. The protein has been extensively used as a stem cell marker for normal and cancerous tissues. May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.

Clone
MD299

Isotype
IgG1

Host species
Mouse

Species Reactivity
Human

Cellular Localization
Secreted

Positive Control
Colonic adenocarcinoma, kidney, muscle

Applications
IHC, Flow Cyt., IF, WB

Intended Use
Research Use Only

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