CD117/c-Kit [C117/370]

Member of the Tyrosine Kinase Receptor (TKRs) and highly homologous to receptor PDF and CSF-1. Activation of c-Kit tyrosine kinase by SCF (Stem Cell factor) leads to autophosphorylation and association of c-Kit with substrate PI3K. CD117 is a marker for Mast cell and gastrointerstinal stroma tumor. This anti-CD117 has been validated with excellent staining result by NordiQC, an independent scientific organization, promoting the quality of immunohistochemistry for pathology laboratories.