CCL17 (TARC) Polyclonal

Chemokines have been implicated in the regulation of stem/progenitor cell proliferation and movement. The CC chemokines TARC or CCL17 (thymus and activation-regulated chemokine, or small inducible cytokine A17) and MDC or CCL22 (macrophage-derived chemokine, or small inducible cytokine A22), are expressed in the thymus and spleen. CC chemokine receptor CCR4, expressed by T helper type 2 polarized cells, is a high affinity receptor for both CCL17 and CCL22. CCL17 is important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to its target tissues. CCL22 is involved in chronic inflammation and dendritic cell and lymphocyte homing. CCL17 and CCL22 lack suppressive activity against immature subsets of myeloid progenitors, which have been stimulated to proliferate by multiple growth factors.