cAMP [ABM486]

$500.00

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Cyclic adenosine monophosphate (cAMP), an intracellular mediator, is important in many signal transduction pathways as a ubiquitous cytoplasmic second messenger due to the involvement of G-Protein Coupled Receptors (GPCR) signaling events where the receptors are activated by different ligands, such as neurotransmitters, hormones, ions, small molecules, peptides, etc. cAMP is generated from ATP by the removal of one pyrophosphate molecule by adenylate cyclase. Adenylate cyclase activation increases the concentration of cAMP in the cell, allowing for the activation of cAMP-dependent protein kinase. The activated kinase amplifies the signal, phosphorylating a number of proteins and altering cellular activity. cAMP is a key intracellular regulator; it mediates the activities of numerous hormones, including ACTH, Glucagon and epinephrine, and plays an important role in modulating calcium transport, regulating gene activation and inducing physiological responses to growth, differentiation and neurotransmission.

Clone
ABM486

Isotype
IgG1

Host species
Mouse

Species Reactivity
Human, mouse, rat

Cellular Localization
Secreted

Positive Control
Lung cancer, kidney, tonsillitis

Applications
IHC, WB

Intended Use
Research Use Only

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