E-Cadherin is a transmembrane glycoprotein, plays an important role in epithelial cell adhesion. A decreased expression of E-Cadherin is associated with metastatic potential and poor prognosis in breast cancer and esophagus cancer. In combination with p120 Catenin or Cytokeratin, it is useful for the differentiation between ductal (E-Cadherin positive) and lobular (E-Cadherin negative) breast carcinomas. It may also help in diagnosis of mesothelioma.
Clone
CDH1/1525
Isotype
IgG1k
Host species
Mouse
Species Reactivity
Human
Cellular Localization
Membrane
Positive Control
Colon, colon carcinoma
Applications
Flow Cyt., ICC/IF, IHC, WB
Intended Use
Research Use Only