BDNF Polyclonal

Neurotrophins are composed of at least four family members, including NGF, Brain-derived neurotrophic factor (BDNF), NT-3, and NT-4, and all are known to influence growth, development, differentiation, and survival of neurons. BDNF is crucial for the survival, development, and synaptic plasticity of neurons. Certain common genetic variations (polymorphisms) in the BDNF gene have been associated with an increased risk of developing psychiatric disorders such as bipolar disorder, anxiety, and eating disorders. Evidence shows that BDNF is an important biomarker for the pathogenesis of depression; reduced levels are linked to reduced synaptic plasticity and neuronal atrophy, while elevated levels are associated with survival and neuronal differentiation, which is compatible with the neurogenic hypothesis of depression.