AGK/MULK Polyclonal

AGK (acylglycerol kinase), also known as MULK (multi-substrate lipid kinase), is a 422 amino acid protein that phosphorylates monoacylglycerol and diacylglycerol to generate bioactive phospholipids lysophosphatidic acid and phosphatidic acid, respectively. It is highly expressed in muscle, heart, kidney and brain. Containing. When overexpressed, AGK increases the production and secretion of LPA, thereby transactivating EGFR and ERK signaling pathways, which in turn lead to increased cell growth. Due to its involvement of LPA overproduction, Research studies show that the kinase activity of AGK is required for the activation of PI3K-mTOR signaling and the subsequent enhancement of glycolysis in activated CD8+ T cells. Therefore, AGK is essential for the growth, proliferation, and antitumor function of activated CD8+ T cells. AGK is also implicated in the initiation and progression of prostate cancer.