ADAM8/CD156 Polyclonal

ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFα and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (Integrin ligand), a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion, and intracellular signaling. ADAM 8 (CD156, MS2) is a 824 amino acid protein that contains a 16 amino acid signal peptide, a 637 amino acid extracellular region, a 25 amino acid transmembrane region and a 146 amino acid cytoplasmic region which possesses a cytoplasmic consensus Src homology 3 (SH3)-binding domain.