8 Hydroxyguanosine (8-OHdG) [15A3]

DNA or RNA damage can hinder the ability of a cell to carry out its function and can significantly increase the likelihood of tumor formation. One of the causes of damaged DNA and RNA is oxidation of the bases. 8-hydroxy-2′-deoxyguanosine, 8 hydroxyguanine (8-OHdG) and 8-hydroxyguanosine are all markers of oxidative damage to RNA and DNA. 8-hydroxy-2′-deoxyguanosine is produced by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. 8-OHdG is one of the major base lesions involved in mutagenesis and is caused by ionizing radiation and radiomimetic agents. 8-hydroxy-guanosine induces a transversion of G to T in DNA, which may be mutagenic. This antibody has applications in the development of immunoassays that can monitor 8OHdG excretion in the urine and serve as a biomarker of oxidative stress. Industrial uses may extend to the dietary supplement manufacturers, who could benefit from an immunoassay that could be used to test the effectiveness of antioxidants and other nutraceuticals.