5T4 [EPR5529]

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5T4 is a 72 kDa transmembrane glycoprotein that exhibits restricted expression in human and mouse adult tissues, is upregulated on many carcinomas and tumour expression correlates with poorer clinical outcome in ovarian, gastric and colorectal cancers. mES cells lack cell surface expression of the 5T4 antigen, and both protein and mRNA are rapidly upregulated following induction of differentiation. This proteins expression correlates with downregulation of OCT-4 and Tra-1–60.

Clone
EPR5529

Isotype
IgG

Host species
Rabbit

Species Reactivity
Human, mouse, rat, monkey

Cellular Localization
Human

Positive Control
placenta, endometrial cancer tissues

Applications
IHC

Intended Use
Research Use Only

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