CD180/RP105 Polyclonal

$486.00

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CD180 or RP105, BGP95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression depends on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.

Clone
Polyclonal

Isotype
IgG

Host species
Rabbit

Species Reactivity
Human

Cellular Localization
membrane

Positive Control
spleen tissue lysate

Applications
IHC, WB

Intended Use
Research Use Only

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