Troponin T, Cardiac Muscle (TNNT2) [1C11]

Troponin is a complex of three regulatory proteins (Troponin I, Troponin T and Troponin C) that is integral to muscle contraction in skeletal and cardiac muscle, but not smooth muscle. Troponin T type 2 (TNNT2) is a cardiac Troponin T isoform expressed in the human heart, which is essential for calcium-regulated myofibrillar ATPase activity. Troponin T (TnT) anchors the complex to thin filaments in vertebrate striated muscle, and it functions as a regulatory system for muscle contraction in response to changes to intracellular calcium ion concentrations.