TAB3 Polyclonal

$686.00

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TAB1, TAB2 and TAB3 (for TAK1 binding proteins) interact with the MAPKKK TAK1 in response to various stimuli. TAB1 activates TAK1 in TGF-β mediated signaling. In response to proinflammatory signals, TAB2 complexes with TRAF6 and TAK1, leading to translocation of the complex from the membrane to the cytosol and the subsequent activation of TAK1. TAB3 functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Catalog No. RC0295

Clone
Polyclonal

Isotype
IgG

Host species
Rabbit

Species Reactivity
Human, Mouse

Cellular Localization
membrane

Positive Control
Thyroid cancer, brain

Applications
IHC, WB

Intended Use
Research Use Only

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