Product Description
Steroidogenic factor-1 (SF-1), also known as NR5A1, regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells. Overexpression or overactivity of SF-1 is also reported in some adrenal tumors or endometriosis. Therefore, the spectrum of phenotypes associated with variations in SF-1 is expanding and the importance of this nuclear receptor in human endocrine disease is now firmly established.
Clone
MD176R
Isotype
IgG
Host species
Rabbit
Species Reactivity
Human
Cellular Localization
Nucleus
Positive Control
Adrenocortical carcinoma, testis, ovary, granulosa cell tumor, Leydig cell tumor
Applications
IHC
Intended Use
Research Use Only