Sarcoglycan Gamma/SGCG [MD56R]

$530.00

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The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunit proteins, designated α-, β-, γ- and δ-sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, β- and δ-sarcoglycans are associated with ε-sarcoglycan, a glycoprotein homologous to α-sarcoglycan. Additionally, a complete deficiency in δ-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy.

Catalog No. RM0420

Clone
MD56R

Isotype
IgG

Host species
Rabbit

Species Reactivity
Human, mouse

Cellular Localization
membrane, cytoplasm

Positive Control
heart

Applications
IHC, IP, WB

Intended Use
Research Use Only

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