PRM1 Polyclonal

PRM1 is a 51 amino acid protein. PRM1 substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. PRM1 is expressed in testis. The calculated molecular weight of PRM1 is 9 kDa, but Phosphorylated protein is about 20 kDa. Histones are highly alkaline proteins, whereas protamines are small arginine-rich proteins. During spermatid differentiation, nuclear remodelling and condensation are associated with the sequential displacement of histones by transition proteins and then by protamines, namely protamine 1 (PRM1) and protamine 2 (PRM2). Protamines allow for denser packaging of DNA in the spermatozoon compared with histones. Therefore, protamines are believed to play important roles in chromatin condensation, suppression of transcription, protection of the haploid male genome, determination of sperm shape and production of offspring.