PELP1 [1B11E4]

Proline-, glutamic acid- and leucine-rich protein 1 (UniProt Q8IZL8; also known as Modulator of non-genomic activity of estrogen receptor, p160, Proline and glutamic acid rich nuclear protein, Transcription factor HMX3) is encoded by the PELP1 (Also known as HMX3, MNAR, P160) gene in human (Gene ID 27043). PELP1 functions as scaffolding protein and mediates protein–protein interactions in cellular processes involving both genomic and extranuclear signaling pathways. Multiple structural domains allow PELP1 to interact with various steroid receptors (SRs) to modulate their activity as either corepressor or coactivator. Dysregulation of PELP1 expression has been observed in breast, ovarian, endometrial, brain, and prostate cancers.