PAX7 [SPM613]

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The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma).

Catalog No. MC0984, MC0984RTU7

Clone
SPM613

Isotype
IgG1k

Host species
Mouse

Species Reactivity
Human+Q1420

Cellular Localization
nucleus

Positive Control
ovarian serous ca

Applications
IHC

Intended Use
Research Use Only

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