This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Catalog No. MC0291, MC0291RTU7
Clone
F2
Isotype
IgG2a/k
Host species
Mouse
Species Reactivity
Human
Cellular Localization
nucle+Q1+R1399
Positive Control
brain+S1399
Applications
ELISA, IF, IHC, IP, WB
Intended Use
Research Use Only