Oct-4 (POU5F1) is a transcription factor highly eexpressed in undifferentiated embryonic stem cells and mbryonic germ cells. A network of key factors that includes Oct-4, Nanog, and Sox2 is necessary for the maintenance of pluripotent potential, and downregulation of Oct-4 has been shown to trigger cell differentiation. Research studies have demonstrated that Oct-4 is a useful germ cell tumor marker. Oct-4 exists as two splice variants, Oct-4A and Oct-4B. Recent studies have suggested that the Oct-4A isoform has the ability to confer and sustain pluripotency, while Oct-4B may exist in some somatic, non-pluripotent cells.
Clone
MD37R
Isotype
IgG
Host species
Rabbit
Species Reactivity
Human
Cellular Localization
Nucleus
Positive Control
Seminoma and dysgerminoma of ovary tissues
Applications
Flow Cyt, CHIP, ICC, IF, IHC, WB
Intended Use
Research Use Only