eIF4E [A10]

“Eukaryotic initiation factor 4E (eIF-4E), a 25-kDa cap binding protein, delivers cellular mRNAs to the eIF4F translation initiation complex by binding the 5′-cap structure of these mRNAs. Studies suggested that increased expression and activity of eIF-4E might be one of the key effects on oncogene expression, resulting in neoplastic transformation. eIF-4E is overexpressed in many types of cancers, including carcinoma of the breast, colon, bladder, cervix, lung, and squamous cell carcinoma of the head and neck. Increased expression of eIF-4E has been associated with tumor progression in breast cancer, prostate cancer, and acute myeloid leukemia (AML).. High expression of eIF4E is associated with adverse tumor characteristics and predicts poor breast cancer-specific survival.”