DSPP (Dentin Sialophosphoprotein) [LFMb21]

DSPP or Dentin Sialophosphoprotein is a precursor protein that is secreted by odontoblasts and cleaved into dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). DSP is heavily glycosylated but DPP is not. DSP and DPP are principle proteins of the dentin extracellular matrix of the tooth, with DSP having a role in dentinogenesis and DPP binding calcium, facilitating initial mineralization of dentin matrix collagen and regulating the size and shape of the crystals. Mutations in the DSPP gene are associated with DFNA39/DGI1 (deafness, autosomal dominant, 39, with dentinogenesis imperfecta, a disease characterized by progressive heavy-frequency hearing loss, DGI2 (dentinogenesis imperfect 2) and DGI3 (dentinogenesis imperfecta 3), diseases characterized by amber-brown teeth that fracture and shed enamel with wear. This clone does not cross react with DSP.