DNMT1 [DNMT1/2061]

DNMT1 is one of three families of enzymes (DNMT1, DNMT2 and DNMT3) that play a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Abnormal methylation patterns are associated with certain human tumors and developmental abnormalities. DNMT1 is responsible for maintenance of the DNA methylation pattern after DNA replication. DNMT1 is the major methyltransferase responsible for methylating DNA. It is widely expressed in normal tissue and increased expression has been observed in many types of cancers. Overexpression of DNMT1 has been associated with early cancer development and cancer progression.