It reacts with keratin 5 (58kDa) and keratin 8 (52.5kDa). Simple epithelia express cytokeratin 8 in combination with 18. On the other hand, basal cells of stratified epithelia express cytokeratin 5 paired with 14. This antibody therefore, reacts with a wide range of epithelia and their carcinomas.
Clone
C-50
Isotype
IgG1k
Host species
Mouse
Species Reactivity
Human, pig, mouse, rat, hamster, cow, dog, sheep
Cellular Localization
cytoplasm
Positive Control
HepG2 or A431 cells. Skin or Squamous cell carcinoma
Applications
Flow Cyt, ICC/IF, IHC, WB
Intended Use
Research Use Only