Cytokeratin 18 [DC10]

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Cytokeratin 18 (CK18) is intermediate filament phosphoglycoprotein that is expressed in simple and glandular and transitional epithelial cells but not in stratified epithelial cells. CK18 is often co-expressed with CK8. CK8/18 is the major keratin pair in simple-type epithelia. Adenocarcinomas originated from simple and glandular epithelium showed CK18 positive staining. In squamous carcinoma, poorly differentiated tumor cells show CK18 reactivity. Loss of CK 18 expression is associated with progression of breast carcinoma.

Clone
DC10

Isotype
IgG1

Host species
Mouse

Species Reactivity
Human

Cellular Localization
cytoplasm

Positive Control
breast, breast ca

Applications
Flow Cyt., IF, IHC, WB

Intended Use
Research Use Only

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