Cytokeratin 15 [MD90R]

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Cytokeratin 15 (CK15) is involved in the development of stratified epithelia from one-layered polar epithelia and continues to be expressed in several adult epithelial tissues. It labels the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. Although CK15 in normal hair follicles was virtually absent from hair bulbs, it was expressed by a subset of keratinocytes in the outer root sheath. In human conjunctival epithelium, strong expression of CK15 was observed in basal cells, whereas Cytokeratin 19 was expressed in both basal and suprabasal layers. CK15 may be used to differentiate primary from metastatic skin cancer. It may be a useful stem cell marker for hair follicle and breast epithelium.

Clone
MD90R

Isotype
IgG

Host species
Rabbit

Species Reactivity
Human, rat, cow

Cellular Localization
cytoplasm

Positive Control
skin, skin ca

Applications
Flow Cyt., IHC

Intended Use
Research Use Only

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