Claudin 7 Polyclonal

Claudin-7, encoded by the CLDN7 gene, is a member of the claudin family. Claudin-7 is a transmembrane protein involved in the formation of tight junctions between epithelial cells.1 The Claudin family of proteins are involved in critical roles of cellular polarity, signal transductions, and have been implicated in the pathogenesis of various human neoplasms including chromophobe renal cell carcinoma. Claudin-7 could be a useful immunohistochemical marker for the distinction and identification of chromophobe renal cell carcinoma. Claudin-7 expression is down-regulated in colorectal cancer (CRC) and lung cancer tissues and loss of Claudin-7 is associated with the degree of cancer cell differentiation and metastasis. While Claudin-7 downregulation was found in Esophageal, Head/Neck, and Prostate Cancers, overexpression of Claudin-7 is found in many Ovarian Cancers and may also lead to increased tumor invasiveness.