Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27. It is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NFkB and SAPK/JNK and induces apoptosis.
Clone
LPFS2/2034R
Isotype
IgG
Host species
Rabbit
Species Reactivity
Human
Cellular Localization
membrane
Positive Control
Human peripheral blood lymphocytes. Human tonsil and lymph node
Applications
IHC
Intended Use
Research Use Only