Catenin Beta is a key regulatory protein involved in cell adhesion and signal transduction through the Wnt pathway, and plays important roles in development, cellular proliferation, and differentiation. Mutations in the Beta-Catenin gene CTNNB1 leading to stabilization of Beta-Catenin in the cytoplasm and translocation to the nucleus have been implicated in various forms of tumor including familial adenomatous polyposis, fibromatosis, solitary fibrous tumors and endometrial carcinoma. A nuclear accumulation of Beta-Catenin in fibromatosis (desmoid tumor) in various locations including breast and mesentery is useful in the differentiation of this tumor from other fibroblast like lesions.
Clone
15B8
Isotype
IgG1k
Host species
Mouse
Species Reactivity
Human, mouse, rat, cow, dog, chicken
Cellular Localization
Cytoplasm, membrane
Positive Control
Fibromatosis of breast or abdomen
Applications
Flow Cyt., IF, IHC, WB
Intended Use
Research Use Only