SIRT1/SIR2 [MD433]

SIRT1, also known as SIR2 or SIR2L1, is a pivotal member of the sirtuin family, and functions as an NAD⁺-dependent deacetylase that plays a critical role in regulating various cellular processes, including transcriptional regulation, DNA damage repair, cell cycle progression, and aging. By deacetylating key substrates such as the tumor suppressor protein p53, SIRT1 modulates essential pathways involved in stress responses, metabolic control, and longevity, making SIRT1 a vital target for research into age-related diseases, cancer, and metabolic disorders.