CD9 [MD422]

CD9, also known as Tetraspanin-29 or p24, belongs to the tetraspanin family of cell surface glycoproteins, and is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2). CD9 plays a role in dendritic cell migration, megakaryocyte differentiation, and homing of cord blood CD34+ hematopoietic progenitors to the bone marrow. In addition, downregulation of CD9 expression is associated with poor prognosis and progression of several types of cancer. Additional research identified CD9 as an abundant component of exosomes and may play some role in the fusion of these secreted membrane vesicles with recipient cells. CD9 is essential in platelet aggregation and clot formation. This antibody is a reliable tool for studying the function and regulatory mechanisms of this key glycoprotein in health and disease.