CLEC14A/EGFR5 Polyclonal

CLEC14A (C-type lectin domain family 14 member A), also known as EGFR-5 (epidermal growth factor receptor 5), is a protein expressed on the surface of endothelial cells. It plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer’s disease (AD). Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. Studies reported that it is upregulated in many solid tumors including those of the ovary, prostate, breast, liver, bladder, kidney and lung. This may partly reflect the reduced flow rate often present within tumor vasculature; however, recent studies indicate that, in cancer, CLEC14A expression may be regulated by other pathways.