CML (pan Nε-Carboxymethyl Lysine) Polyclonal

Nε (N epsilon)- or N6-Carboxymethyl Lysine (CML), is an advanced glycation end-product (AGE). CML has been the most used marker for AGEs in food analysis. CML-RAGE (Receptor for AGE) interaction triggers processes intimately linked to accelerated vascular and inflammatory complications that typify disorders in which inflammation is an established component. Recent studies show that gut microbiota mediates an aging-associated decline in gut barrier function, allowing AGEs to leak into the bloodstream from the gut and impairing microglial function in the brain. It is suggested that the amount of CML in human blood samples may correlated with age. A humanized monoclonal antibody which binds to Nε-Carboxymethyl Lysine shows considerable promise as a possible therapeutic agent for treating pancreatic cancer. The antibody recognizes proteins or peptides with carboxylmethylated lysine residues. No cross reation with acetylated or methylated proteins/peptides.