LRRK2/Dardarin/PARK8 [MD406]

The gene LRRK2 (leucine-rich repeat kinase 2) encodes multidomain protein containing three conserved domains that include a leucine-rich repeat (LRR), a tyrosine kinase catalytic domain (TyrKc) and a WD40 domain. Studies show that various genes and loci are linked to Parkinson’s disease (PD), including α-synuclein/PARK1&4, parkin/PARK2, UCH-L1/PARK5, PINK1/PARK6, DJ-1/PARK7, LRRK2/PARK8, synphilin-1, and NR4A2. Mutations in LRRK2 are a common genetic factor in Parkinson’s disease, the G2019S mutation being the most prevalent. IHC helps researchers study LRRK2 expression in affected brain regions and potential value of LRRK2 as a therapeutic target for treatment of PD.