Urotensin 2 (UTS2) Polyclonal

UTS2 (Urotensin 2), a potent vasoconstrictor, plays a critical role in cardiovascular physiology and pathology, particularly in regulating blood pressure and cardiac function. This 11-amino acid peptide is derived from a precursor protein and remains highly conserved across species, with its cyclic structure being essential for biological activity. It acts as an endogenous ligand for the orphan G-protein-coupled receptor (GPR14). Urotensin II exists in both vascular and cardiac tissues, including significant presence in coronary atheroma, highlighting its importance in cardiovascular health. Urotensin II interacts with G protein-coupled receptor GPR14, which mediates effects on vascular smooth muscle contraction. Urotensin II may function as an autocrine and paracrine hormone, contributing to ventricular hypertrophy development in response to chronic hypoxia, thus underscoring its relevance in various cardiovascular diseases.