ABCC2/MRP2 [5C3]

ABCC2, also known as Multidrug Resistance Protein 2 (MRP2), is a gene that provides instructions for producing a 190-kD integral membrane glycoprotein in the canalicular membrane of liver cells which is involved in transporting substances out of cells. Mutations in ABCC2 can lead to conditions like Dubin-Johnson syndrome, where bilirubin and other substances accumulate in the liver. High ABCC2 expression has been linked to resistance to chemotherapy, particularly in cases of lung cancer, pancreatic cancer, and ovarian cancer. ABCC2 expression levels have been shown to correlate with survival outcomes in certain cancers, like breast, ovarian, and colon cancer.