CD136 (RON MST1R) [MD351R]

CD136, also known as MST1R (Macrophage stimulating 1 receptor) and RON (Recepteur d’origine nantais), is a member of the MET proto-oncogene family, and a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. Binding of MSP to CD136 stimulates tyrosine phosphorylation on Tyr 1238 and Tyr 1239. This phosphorylation leads to a up-regulation of CD136 catalytic activity and subsequent activation of downstream signaling molecules. CD136 regulates cell dissociation, motility, and invasion of extracellular matrices. It is thought to play a role in early embryonic development and in the inflammatory response as well as implicated in the progression and metastasis of tumors including those of the breast and colon. It serves as a prognostic marker and therapeutic target for gastroesophageal cancer.