CXCL9 (MIG) [MD353R]

CXCL9 (C-X-C motif chemokine ligand 9), also known as MIG, is a soluble chemokine expressed by multiple cell types, such as endothelial cells, monocytes, and tumor cells. The expression of CXCL9 is upregulated in response to proinflammatory cytokines, such as IFN-γ and TNF-α. CXCL9 binds to CXCR3, Elevation of serum CXCL9 and CXCL10 in ocular sarcoidosis correlates with ocular disease activity and ACE (angiotensin converting enzyme) levels. CXCL9 is one of many chemokines that belong to a group of small, mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of seven transmembrane, G protein-coupled receptors. Research studies have demonstrated production of CXCL9 by tumor cells mediates tumor suppression through the recruitment of tumor antigen-specific T cells.