CKAP4 (CLIMP-63) [MD352]

CKAP4 (cytoskeleton-associated protein 4), also known as CLIMP-63, p63 or ERGIC-63, is a 602 amino acid single-pass type II transmembrane protein that links the rough endoplasmic reticulum to the cytoskeleton. Considered a novel protein in maintaining endoplasmic reticulum morphology, CKAP4 anchors the endoplasmic reticulum to microtubles which is required for maintaining ER spatial distribution during interphase of the cell cycle. CKAP4 can be reversibly palmitoylated and phosphorylated and is a major substrate of the palmitoyl acyltransferase, ZDHHC2. It is suggested that CKAP4 binds with high affinity to an inhibitor of cell proliferation, antiproliferative factor (APF), and blocks its activity on bladder epithelial cells. Two isoforms of CKAP4 exist due to alternative splicing.