Secretogranin 3/SCG3/SgIII Polyclonal

Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A, chromogranin B (secretogranin I) chromogranin C and secretogranin III (SCG3 or Sg III). Secretogranin III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Secretogranin III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Secretogranin III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes. Genetic variations in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.