Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones.
Clone
MD264R
Isotype
IgG
Host species
Rabbit
Species Reactivity
Human
Cellular Localization
nucleus
Positive Control
tonsil, breast ca, lymphoma
Applications
IHC
Intended Use
Research Use Only