HPV 16/18 E6 [C1P5]

Human papillomaviruses (HPVs) are a diverse group of small, non-enveloped, icosahedral dsDNA-based viruses that have a diameter of 52–55 nm. More than 100 different human papillomavirus types have been characterized as either high risk or low risk according to their association with cancer. Low-risk HPVs mostly cause no disease. However, a few low-risk HPV types such as HPV 6 and 11 can cause 90% of warts or papilloma on or around the genitals, anus, mouth or throat which rarely develop into cancer. High-risk HPVs can cause several types of cancer. There are about 14 high-risk HPV types including HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68. Two of these, HPV 16 and HPV 18, are responsible for most HPV-related cancers. Mutational studies show that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The high risk HPV E7 binds to pRB with a higher affinity than do the low risk HPV, and only the high risk HPV E6 form detectable complexes with p53 in vitro. Clone C1P5 detects the early protein E6 of HPV 16 and 18.