HEG1 [MD332]

HEG1 (Sialylated protein HEG homolog 1), a 1381 amino acid protein , is expressed in endothelial cells and smooth muscle cells of heart tissue, contains two EGF-like domains that play a role in calcium-binding events which may regulate concentric heart growth. HEG1 is a heavily glycosylated protein that participates in endothelial cell associations that develop the vascular system, and therefore plays a role in angiogenesis and the microenvironment of cellular adhesion. HEG1 mucin-like membrane protein has also been found to be a sensitive and specific biomarker for malignant mesothelioma in pleural (lung) and peritoneal (abdominal) membranes, and several other rare locations, where it supports the survival and proliferation of mesothelioma cells. HEG1 is potentially a useful prognostic biomarker and therapeutic target for malignant mesothelioma and hepatocellular, thyroid, and ovarian carcinomas.