CD276/B7-H3 [MD235]

T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. CD276, also known B7-homolog 3 (B7-H3) belongs to the B7 immunoglobulin superfamily. Soluble CD276 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, CD276 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of CD276 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. CD276 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating CD276 as a potential therapeutic tool.